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prepectoral

A cross-section from the implant outwards to the skin. Closest to the implant, the compact layer of the membrane, described by the manufacturer as providing a smooth surface towards the device. Above it, the porous layer, described as the side that supports early tissue integration, with small arrows showing cells and vessels entering it from the flap. Above that, the mastectomy flap and skin. A note reminds the reader to confirm orientation in the Instructions for Use for each configuration.
Clinical Insights — 12 October 2026

ExaShape in Practice: Which Configuration, Which Patient, and How to Use It

Why ExaShape, in which cases, which configuration, and how it is used in theatre, from the flap decision to the refinement stage.

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Three horizontal timelines running from implantation to about a year. Biological matrix: host cells infiltrate the collagen scaffold, new vessels grow into it, and it is gradually remodelled into host tissue that becomes part of the soft-tissue cover. Absorbable synthetic mesh: the polymer provides temporary support while it is surrounded by host tissue, then is resorbed over months, leaving the tissue that formed around it. Permanent synthetic mesh: the polymer is surrounded and incorporated by fibrous tissue and remains in place indefinitely. A note states that only the first adds to the cover by becoming tissue, and that the timing varies by product.
Clinical Insights — 06 October 2026

Biologic or Synthetic Mesh in Breast Reconstruction: The Evidence and the Trade-Offs

The randomised head-to-heads favour synthetic mesh on seroma; biological matrices offer integration into thin cover. The choice is made patient by patient.

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A forest plot on a logarithmic scale from 0.01 to 10, with a vertical line at 1 meaning no difference and values to the left favouring prepectoral placement. Three outcomes have intervals entirely left of 1: animation deformity, odds ratio 0.02 with interval 0.00 to 0.25; capsular contracture, 0.54 with interval 0.32 to 0.92; prosthesis failure, 0.58 with interval 0.42 to 0.80. Six outcomes have intervals crossing 1, meaning no significant difference: overall complications 0.83, seroma 1.21, haematoma 0.76, infection 0.87, skin flap necrosis 0.70, and recurrence 1.31.
Clinical Insights — 27 September 2026

Prepectoral or Subpectoral: What the Evidence Now Shows

Pooled data favour prepectoral placement on three outcomes and disfavour it on none. The evidence is consistent but observational, and the first…

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Two timelines running left to right. Direct-to-implant: mastectomy and definitive implant in one operation, then healing, then optional refinement such as fat grafting. Two-stage: mastectomy with a tissue expander, then a series of expansion visits over several weeks to months, then a second operation to exchange the expander for the definitive implant, then optional refinement. A note states that the first operation decides which line the patient is on, and that the decision rests on the mastectomy flap.
Clinical Insights — 24 September 2026

Direct-to-Implant or Two-Stage: Reading a Meta-Analysis, a Trial and a Cohort Together

A meta-analysis, a randomised trial and a prospective cohort give three different answers. Selection on the mastectomy flap explains all three.

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The same implant drawn in two planes. Subpectoral, it sits under the pectoralis major, which has been divided along its lower border: the muscle gives extra soft-tissue cover over the upper pole, but it now contracts across the device, which is the mechanism of animation deformity and of post-operative pain. Prepectoral, the implant sits on the muscle, wrapped in a matrix and covered by the mastectomy flap alone: the muscle is left whole and undisturbed, so there is no animation and less early pain, and in exchange every demand shifts onto the quality of the flap and the soft-tissue cover above it.
Clinical Insights — 10 September 2026

Prepectoral or Subpectoral: What Changes When the Plane Changes

Prepectoral placement moves the burden from the muscle to the mastectomy flap. An improvement where the flap can carry it, a mistake…

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hybrid-breast-reconstruction-implant-plus-fat-grafting-01
Clinical Insights — 18 August 2026

Hybrid Breast Reconstruction: Combining an Implant, Matrix Support and Fat Grafting

Implant for structure, fat for the living envelope, matrix for support: the rationale, technique and published outcomes of hybrid reconstruction.

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radiotherapy-implant-based-breast-reconstruction-01
Clinical Insights — 15 August 2026

Radiotherapy and Implant-Based Breast Reconstruction: Timing, Plane and Evidence

What PMRT does to implant-based reconstruction, the timing debate, the prepectoral question and the role of matrix support and fat grafting.

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dti-cover-01
Clinical Insights — 03 August 2026

Direct-to-Implant Breast Reconstruction: Patient Selection, Technique and Evidence

A professional overview of DTI reconstruction: the selection criteria, the cautions, and where soft-tissue matrix support fits.

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prepec-subpec-cover-01
Clinical Insights — 31 July 2026

Prepectoral vs Subpectoral Breast Reconstruction: An Evidence-Based Comparison

Above or below the muscle? A sourced, even-handed comparison of prepectoral and subpectoral implant-based breast reconstruction.

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Innovators in breast reconstruction surgery. CE-marked biological membranes and surgical support devices. Founded 2020, Rome, Italy.

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