Advanced Biomedical Concept · EXAFAT

The Closed
Loop, Purified

EXAFAT is a closed-loop fat-dialysis system — harvest, wash, concentrate and inject without a single open transfer. Watch adipose tissue pass a 50-micron membrane that strips blood, oil and fluid while retaining viable fat and its regenerative stromal-vascular fraction.

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Interactive · Fat-Grafting Evidence Explorer

The Numbers, With Their Sources

Select a measure to explore the published data behind autologous fat grafting in breast reconstruction — plus EXAFAT's own purification-yield figures, kept clearly separate.

⚠ Two kinds of data — kept apart

The peer-reviewed figures below describe autologous fat grafting in general, pooled from separate studies with different cohorts and definitions — not device-specific EXAFAT outcomes. The purification-yield figures are manufacturer bench data, not peer-reviewed, and are labelled as such. Neither set is a controlled head-to-head clinical claim for the device.

Complication Rates — Fat Grafting

Reported rate · lower is better

The System · Closed-Loop Workflow

One Sterile Circuit, Four Steps

From lipoaspiration to microinjection, the graft never leaves the sealed system — no open decanting, no airborne exposure, a standardised and reproducible process every case.

Step 01

Atraumatic Harvest

Low-pressure lipoaspiration (≤300 mmHg) through blunt cannulas collects adipose directly into the sealed circuit, minimising shear.

Step 02

Wash & Filter

The aspirate is gently washed across a 50-micron membrane; blood, free oil, debris and tumescent fluid pass through and are discarded.

Step 03

Concentrate

Continued filtration reduces the aqueous fraction, yielding a purified, concentrated graft with a consistent, reproducible composition.

Step 04

Inject

Prepared fat is delivered from the closed system through fine blunt cannulas in small aliquots — no open transfer at any stage.

Mechanism & workflow as described in EXAFAT device literature. See the fat dialysis guide and the device Instructions for Use for full detail.

The Record · Fat-Grafting Science

The Evidence Foundation

Landmark publications establishing the safety, regenerative biology and oncological record of autologous fat grafting in the breast.

2007
Coleman & Saboeiro revisit fat grafting to the breast — establishing safety, efficacy and the dependence of outcome on gentle processing.
2007
Rigotti et al. show adipose-derived stem cells in lipoaspirate can heal radiotherapy-damaged tissue — the regenerative rationale.
2012
Petit et al. report a 321-patient multicentre cohort finding no significant rise in locoregional recurrence after lipofilling.
2016
Groen et al. systematically review 1,330 procedures across 18 studies — 8.6% minor / 3.5% major complications, >80% satisfaction.

Bring the Closed Loop to Your OR

One sterile, ready-to-use kit for the complete procedure. Request the EXAFAT clinical dossier and IFU, or talk to our team about distribution.

Request the Dossier EXAFAT Product Fat Grafting Guide

References

  1. Coleman SR, Saboeiro AP. Fat grafting to the breast revisited: safety and efficacy. Plast Reconstr Surg. 2007;119(3):775–785. DOI: 10.1097/01.prs.0000252001.59152.8a.
  2. Rigotti G, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. 2007;119(5):1409–1422. DOI: 10.1097/01.prs.0000256047.47909.71.
  3. Petit JY, et al. Locoregional recurrence risk after lipofilling in breast cancer patients. Ann Oncol. 2012;23(3):582–588. DOI: 10.1093/annonc/mdr158.
  4. Groen JW, et al. Autologous fat grafting in onco-plastic breast reconstruction: a systematic review. J Plast Reconstr Aesthet Surg. 2016;69(6):742–764. DOI: 10.1016/j.bjps.2016.03.019.
Educational use only. Peer-reviewed figures summarise the general autologous fat-grafting literature — they are not device-specific EXAFAT clinical outcomes. Purification-yield figures are manufacturer bench data and are not peer-reviewed. Nothing here is clinical advice, a controlled head-to-head claim, or a substitute for the device Instructions for Use or a clinician's judgement. Reviewed by Advanced Biomedical Concept Medical Team; last reviewed 2026-08-24.