# ABC — Advanced Biomedical Concept

> Innovators in Breast Reconstruction

This file is a curated index for language models and answer engines.
Content may be quoted with attribution to ABC — Advanced Biomedical Concept.
Full text of every article below: https://advancedbioconcept.com/llms-full.txt

Clinical material here is written for healthcare professionals. It is
educational and is not medical advice, a substitute for the instructions
for use of any device, or a regulatory document.

## Products and guides

- [Biological Matrix for Breast Reconstruction](https://advancedbioconcept.com/biological-matrix-for-breast-reconstruction/): A biological matrix is an acellular bovine-pericardium scaffold that supports the implant and pocket in prepectoral breast reconstruction. Learn how it works, how it compares to ADM and mesh, and where ExaShape® fits.
- [Biological Matrix, ADM & Synthetic Mesh: A Clinical Comparison](https://advancedbioconcept.com/biological-matrix-adm-synthetic-mesh-a-clinical-comparison/): Biological matrix, dermal ADM and synthetic mesh compared for implant-based breast reconstruction. Both dermal ADM and bovine pericardium matrix (ExaShape®) are biological (acellular) matrices; synthetic mesh is non-biological. Origin, integration, supply, cost and CE/MDR status.
- [Bioshield Pocket](https://advancedbioconcept.com/bioshield-pocket/): ExaShape Bioshield Pocket: pre-shaped bovine pericardium membrane for implant coverage in breast reconstruction. CE-marked, EU MDR.
- [Bioshield Pocket 3D](https://advancedbioconcept.com/bioshield-pocket-3d/): ExaShape Bioshield Pocket 3D: pre-shaped 3D bovine pericardium pocket for anatomical implant coverage in breast reconstruction. EU MDR.
- [Bioshield Pocket PRO](https://advancedbioconcept.com/bioshield-pocket-pro/): ExaShape Bioshield Pocket Pro: pericardium pocket for revision and complex breast reconstruction cases. CE-marked under EU MDR.
- [Bovine Pericardium in Breast Reconstruction](https://advancedbioconcept.com/bovine-pericardium-breast-reconstruction/): Evidence-based guide to the bovine pericardium biological matrix in prepectoral & DTI breast reconstruction: how these biological matrices work, device selection, clinical evidence & comparison with ADM and synthetic mesh.
- [Bovine Pericardium Matrices Compared](https://advancedbioconcept.com/bovine-pericardium-matrices-compared/): A neutral, sourced comparison of bovine biological matrices for breast reconstruction: ExaShape (purpose-built bovine pericardium) vs Tutomesh/Tutopatch, Veritas (bovine pericardium) and SurgiMend (fetal bovine dermal ADM) — tissue of origin, configurations, regulatory status and evidence. For…
- [Breast Reconstruction Options](https://advancedbioconcept.com/breast-reconstruction-options/): A plain-language guide to breast reconstruction options after mastectomy: implant-based vs flap, immediate vs delayed, prepectoral vs subpectoral, the role of biological matrices and fat grafting, and questions to ask your surgeon. Educational information, not medical advice.
- [Breast Reconstruction Options Explorer](https://advancedbioconcept.com/reconstruction-explorer/): Compare the main types of breast reconstruction — prepectoral, subpectoral, autologous flap, hybrid and fat grafting — in one interactive tool. See how each works and where biological matrix and fat grafting fit.
- [Certifications](https://advancedbioconcept.com/certifications/): ABC devices are CE-marked under EU MDR 2017/745 and manufactured to ISO 13485:2016 in a GMP-certified Quality Management System.
- [Clinical Evidence at a Glance](https://advancedbioconcept.com/clinical-evidence-at-a-glance/): Published breast-reconstruction outcomes visualised: complication rates, implant loss, capsular contracture and evidence-base size for bovine pericardium, ADM and synthetic mesh — each figure sourced and set in context (indicative, not head-to-head).
- [Clinical Guides HUB](https://advancedbioconcept.com/clinical-guides/)
- [Clinical Studies](https://advancedbioconcept.com/clinical-studies/): Peer-reviewed publications, conference abstracts and clinical data on ExaShape® biological membranes and EXAFAT® fat grafting in breast surgery.
- [Contact](https://advancedbioconcept.com/contact/): Contact ABC in Rome: Via Sabotino 2, 00195. Mon–Fri 9:00–18:00 CET. Questions on ExaShape® membranes, EXAFAT® system, samples or partnerships.
- [Cost of biological matrices](https://advancedbioconcept.com/biological-matrix-cost/): A procurement and value-analysis brief on the cost of biological matrices in breast reconstruction: unit price vs total cost per case, bovine pericardium vs ADM cost, supply security, EU MDR/CE status, and a budget-impact framework. Model with the cost-per-case calculator.
- [Cost-Per-Case Calculator](https://advancedbioconcept.com/cost-per-case-calculator/)
- [Decision Simulator](https://advancedbioconcept.com/decision-simulator/)
- [Distributors](https://advancedbioconcept.com/distributors-partners/): Partner with ABC to distribute CE-marked breast reconstruction devices. Clinical training, marketing support and co-marketing in your territory.
- [DRAFT Libra](https://advancedbioconcept.com/draft-libra/)
- [Events](https://advancedbioconcept.com/events/): Live surgical masterclasses, international congresses and hands-on workshops with the ABC team. Find upcoming events for breast reconstruction surgeons.
- [Exafat Exp](https://advancedbioconcept.com/exafat-exp/)
- [Exafat Kit](https://advancedbioconcept.com/exafat-kit/): EXAFAT® closed-circuit fat grafting system with vacuum-locking syringe (~300 mmHg) for harvest, processing and reinjection in one device.
- [Exashape Evidence Library](https://advancedbioconcept.com/exashape-evidence-library/)
- [Exashape Expander](https://advancedbioconcept.com/exashape-expander/): ExaShape Expander: bovine pericardium membrane shaped to support tissue expanders in two-stage breast reconstruction. CE-marked, EU MDR.
- [Exashape Grid](https://advancedbioconcept.com/exashape-grid/): ExaShape Grid: perforated bovine pericardium membrane for drainage and integration in breast and soft-tissue reconstruction. EU MDR.
- [Exashape Line](https://advancedbioconcept.com/exashape-line/): ExaShape® biological matrices from bovine pericardium for breast reconstruction and revision surgery. CE-marked under EU MDR 2017/745.
- [Exashape NAC](https://advancedbioconcept.com/exashape-nac/): ExaShape NAC: bovine pericardium scaffold for nipple-areola complex reconstruction. Supports projection and tissue integration. EU MDR.
- [Exashape Prepec](https://advancedbioconcept.com/exashape-prepec/): ExaShape PREPEC anatomical pericardium membrane for pre-pectoral breast reconstruction. Reduces rippling, supports soft-tissue thickness.
- [Fat Grafting in Breast Reconstruction](https://advancedbioconcept.com/guide-fat-grafting-in-breast-reconstruction/): Evidence-based guide to autologous fat grafting in breast reconstruction: biological mechanism, clinical applications, harvest-to-injection workflow, and how closed-system processing (EXAFAT®) supports graft viability.
- [Flagship — Clinical Evidence Experience](https://advancedbioconcept.com/flagship-clinical-evidence-experience/)
- [Media Kit](https://advancedbioconcept.com/media-kit/): ABC media kit: logos, brand colours, approved messaging, product imagery and social guidelines for press, partners and distributors.
- [Meet the Team](https://advancedbioconcept.com/meet-the-team/): Meet the HCPs, materials engineers and founders behind Advanced Biomedical Concept — the team reimagining breast reconstruction from Rome.
- [Our Science](https://advancedbioconcept.com/science/): How the bovine pericardium biological matrix works in breast reconstruction: decellularised collagen scaffold, host cell repopulation, revascularisation and a low inflammatory response compared with synthetic alternatives.
- [Our Story](https://advancedbioconcept.com/our-story/): Advanced Biomedical Concept was founded in 2020 by surgeons and engineers to reimagine breast reconstruction with biology-first devices.
- [Prepectoral Breast Reconstruction](https://advancedbioconcept.com/prepectoral-breast-reconstruction/): Prepectoral (above-the-muscle) breast reconstruction explained: how it compares to subpectoral techniques, who's a candidate, and the role of biological matrix and fat grafting. Evidence-based clinical guide from Advanced Biomedical Concept.
- [PRODUCTS](https://advancedbioconcept.com/products/): Discover the ABC product portfolio: ExaShape® bovine pericardium biological mesh and EXAFAT® fat grafting system for prepectoral & DTI breast reconstruction. CE-marked, EU MDR.
- [Rigottomia (Rigottomy): The Technique Explained](https://advancedbioconcept.com/rigottomy/): Rigottomia (rigottomy) is a percutaneous release technique that turns tight, scarred or fibrous tissue into a vascularised 3D mesh for autologous fat grafting. Learn how it works, the clinical evidence, and where it is used — scars, burns, tuberous breast and reconstruction.
- [Surgeons/HCP Area](https://advancedbioconcept.com/surgeons-hcp-area/): Resources for healthcare professionals: IFU documents, surgical technique videos, clinical study dossiers, and direct medical team contact.
- [Testimonials & Quotes](https://advancedbioconcept.com/testimonials-quotes/): What healthcare professionals say about ExaShape® biological membranes and the EXAFAT® fat grafting system in real breast reconstruction practice.

## Clinical library

- [Digital Planning in Breast Reconstruction: What the Tools Do Not Do](https://advancedbioconcept.com/digital-planning-tools-breast-reconstruction-surgeons/): Planning as a loop rather than a step, which question each tool answers, and why the most useful thing a vendor can tell you is what their tool does not do.
- [What the CE Mark Tells You, and the Six Questions It Does Not Answer](https://advancedbioconcept.com/medical-device-regulation-evidence-breast-reconstruction/): How an implantable device reaches the European market under EU MDR 2017/745, what conformity assessment certifies, and the evidence questions surgeons still have to ask.
- [Rigottomy in the Irradiated and Reconstructed Chest: Depth and Timing](https://advancedbioconcept.com/rigottomy-depth-planes-and-radiotherapy-timing/): The dermal plexus above, the chest wall or implant below, and a post-radiotherapy window defined by tissue behaviour rather than by an interval in months.
- [Rigottomy Release Mechanics: Why the Cuts Must Not Join Up](https://advancedbioconcept.com/rigottomy-release-mechanics-avoiding-macrocavities/): How percutaneous release converts a fibrous plate into separate micro-cavities, why coalescing releases cause fat necrosis, and what keeps the cavities apart.
- [Prepectoral or Subpectoral: What Changes When the Plane Changes](https://advancedbioconcept.com/prepectoral-vs-subpectoral-plane-selection-dti/): Animation deformity, recovery, flap dependence, rippling and matrix requirement — the prepectoral and subpectoral planes compared as a trade, not a replacement.
- [Reading the Mastectomy Flap: The Decision That Is Still Open in Theatre](https://advancedbioconcept.com/assessing-the-mastectomy-flap-direct-to-implant/): Thickness, colour, capillary refill and dermal bleeding — how the mastectomy flap is assessed intraoperatively, and why direct-to-implant needs a two-stage consent.
- [Planning Fat Grafting Across Sessions: Volume, Staging and the Overfill Trap](https://advancedbioconcept.com/planning-fat-grafting-sessions-volume-and-staging/): Why the recipient bed sets a volume ceiling, why exceeding it reduces retained volume, and how to plan and consent a staged fat grafting sequence.
- [What Actually Determines Fat Graft Retention](https://advancedbioconcept.com/what-determines-fat-graft-retention-surgeons/): Diffusion, the recipient bed, interstitial pressure and parcel geometry — a surgeon-facing analysis of where fat graft retention is really decided.
- [Questions to Ask Your Surgeon Before Breast Reconstruction](https://advancedbioconcept.com/questions-to-ask-before-breast-reconstruction/): The questions worth asking before breast reconstruction, grouped by options, timing, results, risks and recovery, with what a useful answer sounds like.
- [Is Fat Grafting Safe After Breast Cancer? The Oncological Evidence](https://advancedbioconcept.com/oncological-safety-fat-grafting-after-breast-cancer/): Does lipofilling increase recurrence after breast cancer? What meta-analyses and matched cohort studies covering thousands of patients actually show, with sources.
- [Breast Reconstruction Recovery: A Realistic Timeline, Week by Week](https://advancedbioconcept.com/breast-reconstruction-recovery-timeline/): How long recovery from breast reconstruction really takes: the first week, drains, returning to work, when the breast settles, scars and sensation.
- [Hybrid Breast Reconstruction: Combining an Implant, Matrix Support and Fat Grafting](https://advancedbioconcept.com/hybrid-breast-reconstruction-implant-plus-fat-grafting/): How hybrid reconstruction combines an implant for volume with autologous fat grafting for the soft-tissue envelope, usually over a matrix-supported prepectoral pocket.
- [Revision Breast Reconstruction: Why It Happens and What It Involves](https://advancedbioconcept.com/revision-breast-reconstruction/): Why breast reconstructions need revision, from capsular contracture to rippling and malposition, and what each corrective procedure achieves.
- [Radiotherapy and Implant-Based Breast Reconstruction: Timing, Plane and Evidence](https://advancedbioconcept.com/radiotherapy-implant-based-breast-reconstruction/): How post-mastectomy radiotherapy affects implant-based reconstruction: complication data, expander vs implant timing, the prepectoral question and fat grafting.
- [Seroma After Mastectomy and Breast Reconstruction: Causes, Prevention and Management](https://advancedbioconcept.com/seroma-after-mastectomy-and-reconstruction/): Why seromas form after mastectomy and implant reconstruction, what raises the risk, how they are drained and managed, and when fluid signals infection.
- [Matrix Complications in Breast Reconstruction: Seroma, Infection and Red Breast Syndrome](https://advancedbioconcept.com/adm-complications-red-breast-syndrome/): The complications reported with acellular dermal matrix in breast reconstruction: seroma, infection and red breast syndrome, what they are and how they are managed.
- [Mastectomy Flap Necrosis: Risk Factors, Perfusion Assessment and Prevention](https://advancedbioconcept.com/mastectomy-flap-necrosis-risk-assessment/): Why mastectomy skin flaps fail, what ICG angiography adds to clinical judgement, and the intraoperative decisions flap perfusion should drive.
- [Capsular Contracture in Implant-Based Reconstruction: Risk Factors, Prevention and the Role of Matrices](https://advancedbioconcept.com/capsular-contracture-implant-based-reconstruction/): What drives capsular contracture after implant-based breast reconstruction, how it is graded, and what published evidence says about plane and matrix support.
- [Two-Stage Breast Reconstruction: The Expander-to-Implant Pathway Explained](https://advancedbioconcept.com/two-stage-expander-implant-breast-reconstruction/): How two-stage breast reconstruction works: expander placement, the expansion phase, the implant exchange, complications and when teams stage instead of DTI.
- [Animation Deformity After Breast Reconstruction: Causes, Prevention and Correction](https://advancedbioconcept.com/animation-deformity-after-breast-reconstruction/): Why implants move with the chest muscle after subpectoral reconstruction, how often animation deformity occurs, and how prepectoral conversion corrects it.
- [Nipple-Sparing Mastectomy: Candidates, Evidence and Reconstruction](https://advancedbioconcept.com/nipple-sparing-mastectomy-and-reconstruction/): Who is a candidate for nipple-sparing mastectomy, what the oncological evidence shows, and how NSM pairs with modern implant-based reconstruction.
- [Direct-to-Implant Breast Reconstruction: Patient Selection, Technique and Evidence](https://advancedbioconcept.com/direct-to-implant-breast-reconstruction-patient-selection/): Who is a candidate for direct-to-implant (DTI) breast reconstruction? Flap assessment, selection criteria, cautions and the role of matrix support, with sources.
- [Prepectoral vs Subpectoral Breast Reconstruction: An Evidence-Based Comparison](https://advancedbioconcept.com/prepectoral-vs-subpectoral-breast-reconstruction/): Prepectoral vs subpectoral breast reconstruction: pain, animation deformity, complications, radiotherapy and aesthetics compared, with every figure sourced.
- [The Global Evolution of Breast Reconstruction: Synergies at JBO 2026](https://advancedbioconcept.com/the-global-evolution-of-breast-reconstruction-synergies-at-jbo-2026/): A Premier Forum for Oncoplastic Excellence The Jornada Brasileira de Oncoplastia (JBO 2026) is scheduled to take place from July 30 to August 1, 2026, at the…
- [Is Rigottomia Safe? Recovery, Risks and What to Expect](https://advancedbioconcept.com/is-rigottomia-safe-recovery-what-to-expect/): Is rigottomia safe? A plain-language patient guide to the procedure, anaesthetic, recovery, scarring, risks and how many fat grafting sessions to expect.
- [Rigottomia for Tuberous Breast, Scars and Areola Release](https://advancedbioconcept.com/rigottomia-tuberous-breast-scar-release/): How rigottomia releases the fibrous restriction behind tuberous breasts, herniated areolae, scars and burns — then rebuilds shape and volume with fat grafting.
- [Prepectoral, mesh-supported reconstruction: fewer reoperations, better long-term value](https://advancedbioconcept.com/prepectoral-breast-reconstruction-outcomes/): A 10-year study of 501 implant reconstructions after nipple-sparing mastectomy: prepectoral mesh nearly halved reoperations with favorable cost-utility.
- [EXAFAT: The Fat Dialysing System Engineered for Breast Surgery](https://advancedbioconcept.com/exafat-the-fat-dialysing-system-engineered-for-breast-surgery/): How the harvest-to-injection workflow shapes fat grafting outcomes in breast surgery, and why graft material quality sets the ceiling for retention. For HCPs.
- [Questions to Ask Your Surgeon About Breast Reconstruction](https://advancedbioconcept.com/questions-to-ask-your-surgeon-breast-reconstruction/): A practical list of questions to ask your surgeon about breast reconstruction — your options, technique and materials, individual risks and recovery, and outcomes.
- [Choosing a Biological Matrix: A Practical Framework for Reconstructive Surgeons](https://advancedbioconcept.com/choosing-a-biological-matrix-framework-for-surgeons/): A six-part framework for evaluating a biological matrix for breast reconstruction: mechanical properties, integration, processing, consistency, regulatory status and evidence, and handling.
- [Prepectoral Breast Reconstruction: The Role of Biological Matrix and Fat Grafting](https://advancedbioconcept.com/prepectoral-breast-reconstruction-biological-matrix-fat-grafting/): How prepectoral breast reconstruction places the implant above the muscle — and why a biological matrix and fat grafting are the technologies that make it work.
- [Rigottomia and Fat Grafting: Preparing the Recipient Site for Better Graft Take](https://advancedbioconcept.com/rigottomia-fat-grafting-recipient-site-preparation/): How rigottomia (percutaneous release) reconditions the recipient site — releasing fibrosis, expanding volume and improving vascular access — to improve fat graft survival.
- [Recovery After Implant-Based Breast Reconstruction: What to Expect](https://advancedbioconcept.com/recovery-after-implant-breast-reconstruction/): A general guide to recovery after implant-based breast reconstruction — the early days, the first weeks, longer-term settling, and when to seek advice.
- [Reducing Complications in Implant-Based Breast Reconstruction](https://advancedbioconcept.com/reducing-complications-implant-breast-reconstruction-matrix-fat/): How matrix selection and adjunctive fat grafting relate to complications in implant-based breast reconstruction: seroma, infection, skin-flap necrosis, capsular contracture and rippling.
- [Med Tech for Breast Reconstruction: How Technology Is Changing Implant Surgery](https://advancedbioconcept.com/med-tech-for-breast-reconstruction/): How med tech for breast reconstruction — biological matrices, fat grafting technology and planning tools — is enabling muscle-sparing, biology-led implant reconstruction.
- [Mastering the Prepectoral Plane 2.0: Where Clinical Rigor Meets the Future of Surgical Education](https://advancedbioconcept.com/mastering-the-prepectoral-plane-2-0-where-clinical-rigor-meets-the-future-of-surgical-education/): Advanced Biomedical Concept's live surgery training with Prof. Roy de Vita—streamed in 3D—plus the new Libra reconstruction concept. Read the recap.
- [What Is Rigottomia (Rigottomy)? The Fat-Grafting Technique Explained](https://advancedbioconcept.com/what-is-rigottomia-rigottomy-fat-grafting/): What is rigottomia (rigottomy)? A clear guide to the percutaneous technique that releases scarred, fibrous tissue into a mesh so fat grafts can take and survive.
- [Two-Stage Tissue Expander Breast Reconstruction Explained](https://advancedbioconcept.com/two-stage-tissue-expander-breast-reconstruction/): How two-stage breast reconstruction works — a tissue expander followed by the final implant — why it is chosen, and the role of a biological matrix.
- [Using a Biological Matrix in Prepectoral Direct-to-Implant Reconstruction](https://advancedbioconcept.com/biological-matrix-prepectoral-direct-to-implant-technique/): A professional overview of how a biological matrix is used in prepectoral direct-to-implant breast reconstruction: patient selection, pocket coverage, technique principles and fat grafting.
- [Bovine Pericardium Biological Matrix: How It Supports Breast Reconstruction](https://advancedbioconcept.com/bovine-pericardium-biological-matrix-breast-reconstruction/): Why bovine pericardium makes a strong, integrating biological matrix for breast reconstruction — how it is processed, why its collagen structure matters, and where ExaShape fits.
- [Direct-to-Implant (One-Stage) Breast Reconstruction Explained](https://advancedbioconcept.com/direct-to-implant-breast-reconstruction-explained/): What direct-to-implant (single-stage) breast reconstruction is, what makes it possible, who it suits, and how a biological matrix supports a one-operation result.
- [The Clinical Evidence for Biological Matrices in Breast Reconstruction](https://advancedbioconcept.com/the-clinical-evidence-for-biological-matrices-breast-reconstruction/): A surgeon-focused overview of the evidence for biological matrices in breast reconstruction: which outcomes matter, the limits of the literature, and how to appraise a matrix study.
- [What Is a Biological Matrix for Breast Reconstruction? A Clinical Guide](https://advancedbioconcept.com/what-is-a-biological-matrix-for-breast-reconstruction/): A clear clinical guide to the biological matrix for breast reconstruction: what it is, how it integrates with the body, and how it compares to ADM and synthetic mesh.
- [Combining ExaShape and ExaFat: A Med-Tech Approach to Prepectoral Reconstruction](https://advancedbioconcept.com/combining-exashape-exafat-prepectoral-reconstruction/): How ExaShape and ExaFat work together in muscle-sparing prepectoral breast reconstruction — a biological matrix for support and integration, plus cleaner fat for refinement.
- [Breast Reconstruction Options After Mastectomy: A Patient’s Guide](https://advancedbioconcept.com/breast-reconstruction-options-after-mastectomy-guide/): A calm, plain-language guide to breast reconstruction options after mastectomy: implant-based vs. autologous, timing, prepectoral placement, and the role of technology.
- [The Retention Problem: Why Fat Grafting still falls short – and what changes When you fix the Process](https://advancedbioconcept.com/fat-grafting-breast-retention-problem/): Fat grafting retention rates range from 30–80%. The variability isn't biology — it's process. Here's what the evidence says, and what changes when you fix it.
- [ExaFat Explained: Engineering Cleaner Fat for Breast Reconstruction](https://advancedbioconcept.com/exafat-fat-processing-breast-reconstruction/): What ExaFat is and the fat dialysis idea behind it — cleaning lipoaspirate while preserving the regenerative fraction for more predictable fat grafting in breast reconstruction.
- [Fat Grafting in Breast Reconstruction: How It Works and Why Processing Quality Matters](https://advancedbioconcept.com/fat-grafting-breast-reconstruction-processing-quality/): How fat grafting works in breast reconstruction, why graft survival is the key challenge, and how fat processing and the stromal vascular fraction affect results.
- [ExaShape Explained: The Bilayer Bovine Pericardium Matrix](https://advancedbioconcept.com/exashape-bilayer-bovine-pericardium-matrix/): What ExaShape is and the thinking behind its design — a bilayer bovine pericardium biological matrix engineered to support an implant and encourage revascularisation.
- [Is a Biological Matrix Safe? Common Patient Questions Answered](https://advancedbioconcept.com/is-a-biological-matrix-safe-patient-questions/): Plain-language answers to common patient questions about biological matrix safety in breast reconstruction: rejection, risks, animal-derived material and how long it lasts.
- [One Line, Seven Decisions](https://advancedbioconcept.com/one-line-seven-decisions/): Explore the complete ExaShape biological matrix product line. Featuring 7 distinct acellular bovine pericardium configurations—including BioShield Pocket, Grid, and Expander—designed for tailored breast reconstruction. For healthcare professionals.
- [From Membrane to Living Tissue: A 12-Month Timeline](https://advancedbioconcept.com/from-membrane-to-living-tissue-a-12-month-timeline/): Follow the 12-month integration timeline of the ExaShape biological matrix. Learn how this acellular bovine pericardium (ABPM) progresses from implantation to living, patient-specific tissue. For healthcare professionals.
- [Twenty-One Months of Real-World Clinical Data](https://advancedbioconcept.com/twenty-one-months-of-real-world-clinical-data/): Review real-world clinical data for the ExaShape acellular bovine pericardium (ABPM) matrix. A 21.3-month follow-up study shows a 4.3% complication rate and zero cases of severe capsular contracture. For healthcare professionals.
- [The Bilayer, Explained](https://advancedbioconcept.com/the-bilayer-explained/): Discover how the ExaShape bilayer biological matrix uses a compact layer to protect the implant and a porous layer to drive a predictable, four-stage tissue integration process. For healthcare professionals.
- [Not all matrices share a biography | Tool](https://advancedbioconcept.com/not-all-matrices-share-a-biography-tool/): Explore the structural and biological differences between ExaShape acellular bovine pericardium (ABPM) and standard dermal matrices. Trace the 12-month mode of action and tissue integration. For healthcare professionals.
- [Not All Matrices Share a Biography](https://advancedbioconcept.com/not-all-matrices-share-a-biography/): Discover ExaShape, a non-crosslinked acellular bovine pericardium (ABPM) matrix for implant-based breast reconstruction. Its native bilayer design ensures optimal tissue integration and implant stability. For healthcare professionals.
- [Oncoplastic Surgery: Where Cancer Care Meets Reconstruction](https://advancedbioconcept.com/oncoplastic-surgery-breast-reconstruction/): What oncoplastic surgery is — uniting cancer removal with breast preservation and reconstruction — and how biological matrices and fat grafting support its goals.
- [Biological Matrix vs. ADM vs. Synthetic Mesh: How Surgeons Choose](https://advancedbioconcept.com/biological-matrix-vs-adm-vs-synthetic-mesh-how-to-choose/): How biological matrix, acellular dermal matrix (ADM) and synthetic mesh compare for breast reconstruction — and the factors surgeons weigh when choosing between them.
- [Nipple-Sparing Mastectomy and Reconstruction: What It Involves](https://advancedbioconcept.com/nipple-sparing-mastectomy-reconstruction/): What nipple-sparing mastectomy is, who it may suit, and why preserving the skin envelope and nipple gives implant-based breast reconstruction a more natural result.
- [Radiotherapy and Breast Reconstruction: Managing the Irradiated Field](https://advancedbioconcept.com/radiotherapy-and-breast-reconstruction/): How radiotherapy affects breast reconstruction — its impact on tissue quality and healing, the timing dilemma, and why integration and tissue quality matter more.
- [Immediate vs. Delayed Breast Reconstruction: How Timing Is Decided](https://advancedbioconcept.com/immediate-vs-delayed-breast-reconstruction/): The difference between immediate and delayed breast reconstruction, the advantages of each, and why radiotherapy and the oncologic plan often decide the timing.
- [Breast Cancer and Reconstruction: Understanding the Oncologic Pathway](https://advancedbioconcept.com/breast-cancer-and-reconstruction-oncologic-pathway/): How breast reconstruction fits within the wider cancer journey — surgery, adjuvant therapy and timing — and how oncologic care shapes reconstructive options.
- [Stop Tailoring, Start Positioning](https://advancedbioconcept.com/11535-2/): Discover the Exashape Bioshield Pocket. Move from manual mesh tailoring to strategic positioning backed by the largest multicentric ABPM clinical studies.
- [The Biological Imperative: A Synthesis of Findings from The Integrity Initiative](https://advancedbioconcept.com/the-biological-imperative-a-synthesis-of-findings-from-the-integrity-initiative/): A definitive clinical synthesis of advanced prepectoral breast reconstruction, evaluating acellular bovine pericardium matrices vs. traditional ADM.
- [Advanced Biomedical Concept: 2026 Clinical Milestones](https://advancedbioconcept.com/advanced-biomedical-concept-2026-clinical-milestones/): Explore Advanced Biomedical Concept's 2026 milestones across Europe & Brazil, featuring ExaShape 3D, Exafat hybrid surgery, and the ABC e-learning platform.
- [Exashape™ in Prepectoral Breast Reconstruction: Key Findings Visualised](https://advancedbioconcept.com/exashape-in-prepectoral-breast-reconstruction-key-findings-visualised-2/): Explore interactive, animated visualizations of published prepectoral breast reconstruction data—covering demographics, complications, and quality of life.
- [A Comparative Analysis of Long-Term Clinical Pathways](https://advancedbioconcept.com/a-comparative-analysis-of-long-term-clinical-pathways/): Evaluate 5-year data from Salgarello et al. (2025) and De Vita et al. (2024) on capsular contracture, surgical burden, and bovine pericardium matrices.
- [A New Partnership for Clinical Excellence](https://advancedbioconcept.com/11502-2/): ExaShape launches in Sweden and Denmark through an exclusive partnership with Apgar, bringing advanced pre-pectoral breast reconstruction to the Nordics.
- [The Biology of Bio-Replacement](https://advancedbioconcept.com/the-biology-of-bio-replacement/): Discover ExaShape ABPM, a non-crosslinked biological matrix for prepectoral reconstruction. Engineered for M2 macrophage response and rapid neovascularization.
- [Surgeon Spotlight | Restoring Femininity](https://advancedbioconcept.com/surgeon-spotlight-restoring-femininity/): Discover how Dr. Diletta Maria Pierazzi uses innovative pre-pectoral techniques for immediate breast reconstruction. Read the interview for expert insights.
- [Patient-Reported Outcomes in Breast Reconstruction: Why BREAST-Q Matters](https://advancedbioconcept.com/patient-reported-outcomes-breast-reconstruction-breast-q/): Why patient-reported outcomes and the BREAST-Q are central to measuring breast reconstruction — capturing satisfaction, comfort and quality of life, not just appearance.
- [Complication Rates in Implant-Based Breast Reconstruction: What the Evidence Shows](https://advancedbioconcept.com/complication-rates-implant-breast-reconstruction-evidence/): How to interpret complication rates in implant-based breast reconstruction — the common complications, why rates vary so widely, and which risk factors are modifiable.
- [How to Read a Breast Reconstruction Clinical Study: Outcomes That Matter](https://advancedbioconcept.com/reading-a-breast-reconstruction-clinical-study/): A plain-language guide to appraising breast reconstruction studies: study design, meaningful endpoints, confounding, follow-up, and product-specific vs. category evidence.
- [Xenograft vs. Allograft Biological Matrix: Origins and What They Mean](https://advancedbioconcept.com/xenograft-vs-allograft-biological-matrix/): The difference between xenograft (animal-derived) and allograft (human donor) biological matrices for breast reconstruction — and what it means for consistency, supply and structure.
- [How a Biological Matrix Integrates: Revascularisation and Tissue Remodelling](https://advancedbioconcept.com/how-a-biological-matrix-integrates-revascularisation/): What integration really means: how a biological matrix is repopulated and revascularised into living tissue, why it matters, and what encapsulation looks like instead.
- [How Biological Matrices Are Made: Decellularisation and Sterilisation Explained](https://advancedbioconcept.com/how-biological-matrices-are-processed-decellularisation/): How a biological matrix is processed — decellularisation to remove donor cells, sterilisation, and the balance that preserves collagen structure, immunogenicity and consistency.
- [Types of Biological Matrices: Sources, Structure and How They Differ](https://advancedbioconcept.com/types-of-biological-matrices-explained/): A guide to the types of biological matrix used in breast reconstruction — xenograft vs. allograft, dermal vs. pericardial vs. bilayer — and why they are not interchangeable.
- [The Breast Reconstruction Industry: Market Landscape and the Rise of Med Tech](https://advancedbioconcept.com/breast-reconstruction-industry-landscape/): An overview of the breast reconstruction industry — what drives demand, the med-tech layer of biological matrices and fat processing, and the European evidence regime.
- [The Future of Breast Reconstruction: What Med Tech Will Change Next](https://advancedbioconcept.com/future-of-breast-reconstruction/): Where breast reconstruction is heading: muscle-sparing as default, smarter biomaterials, better fat processing, and data-driven, personalised care led by med tech.
- [A History of Breast Reconstruction: From Early Flaps to Biological Matrices](https://advancedbioconcept.com/history-of-breast-reconstruction/): How breast reconstruction evolved from tissue flaps and muscle-covered implants to muscle-sparing, biology-led techniques enabled by the biological matrix and fat grafting.
- [Exashape™ in Prepectoral Breast Reconstruction: Key Findings Visualised](https://advancedbioconcept.com/exashape-in-prepectoral-breast-reconstruction-key-findings-visualised/): Medical literature is dense by necessity, but that doesn’t mean it has to be inaccessible. We created these animated visualisations to make the study’s key f…
- [The Power of the Female Perspective](https://advancedbioconcept.com/the-power-of-the-female-perspective/): International Women’s Day 2026 marks a pivotal moment in the surgical world. In the specialized field of breast reconstruction, the "human touch" has evolved…
- [An important new milestone for Advanced Biomedical Concept](https://advancedbioconcept.com/an-important-new-milestone-for-advanced-biomedical-concept/): 📅 On 19 January, we will officially launch the ABC E-Learning Platform, developed exclusively for our partners and internal commercial teams. 👉The E-Learning…
- [A Landmark Week for Brazilian Reconstructive Surgery](https://advancedbioconcept.com/a-landmark-week-for-brazilian-reconstructive-surgery/): SÃO PAULO – Last week marked a historic milestone for the Brazilian medical community as Advanced Biomedical Concept and HPF Surgical officially introduced t…
- [Mastering the Prepectoral Plane: Advanced Training in Rome](https://advancedbioconcept.com/mastering-the-prepectoral-plane-advanced-training-in-rome/): ROME, ITALY – On February 3–4, 2024, Advanced Biomedical Concept (ABC) hosted a premier international educational initiative titled "Mastering the Prepectora…
- [The New Benchmark in Surgical Education](https://advancedbioconcept.com/the-new-benchmark-in-surgical-education/): Rome’s First 3D Stereoscopic 4K HD Live Training for Breast Reconstruction Innovation Meets Immersion at the Regina Elena Cancer Institute Medical education…
- [The future of prepectoral reconstruction is arriving in São Paulo 🇧🇷.](https://advancedbioconcept.com/the-future-of-prepectoral-reconstruction-is-arriving-in-sao-paulo-%f0%9f%87%a7%f0%9f%87%b7/): The future of prepectoral reconstruction is arriving in São Paulo 🇧🇷. This week, Flavio Nanni and Max Riccio from Advanced Biomedical Concept and HPF Surgica…
- [IT’S OFFICIAL, WE’RE LANDING IN BRAZIL!](https://advancedbioconcept.com/its-official-were-landing-in-brazil/): 💫 We are thrilled to announce that, after an intense and rewarding registration process with ANVISA, we are ready to launch #ExaShape in the promising Brazil…
- [ABS CONFERENCE 2025 in Birmingham](https://advancedbioconcept.com/abs-conference-2025-in-birmingham/): 🤩 We had the pleasure of attending two enriching days at the #ABSConference2025, held on 19–20 May at the ICC in Birmingham 🤗 A special thanks to our partner…
- [Exafat has been launched in the market](https://advancedbioconcept.com/new-product-exafat-has-been-launched-in-the-market/): 🎉 Exciting News! 🎉 🤩 We’re thrilled to welcome a ground breaking addition to the Advanced Biomedical Concept portfolio!💯 This new product is set to improve b…
- [First surgery using Bioshield pocket 3D at Guy’s and St Thomas’ NHS Foundation Trust (London)](https://advancedbioconcept.com/first-surgery-using-bioshield-pocket-3d-at-guys-and-st-thomas-nhs-foundation-trust-london/): ✨ milestone ALERT ✨ We’re proud to announce the first use of Exashape 3D at Guy's and St Thomas' NHS Foundation Trust (London)!👏 This landmark case was led b…
- [First surgery using Bioshield Pocket 3D at King’s College Hospital in London with dr. Abdul Kasem](https://advancedbioconcept.com/first-surgery-using-bioshield-pocket-3d-at-kings-college-hospital-in-london-with-dr-abdul-kasem/): ✨ 2025 kicks off with exciting milestones! ✨ We’re proud to share the first UK surgery using our new product, Bioshield Pocket 3D.📍 On March 18th at King’s C…
- [BBM • Barcelona Breast Meeting 2025](https://advancedbioconcept.com/barcelona-breast-meeting-bbm-in-barcelona/): ✨ Snapshots from BBM Congress:Advancing Breast Reconstruction ✨ As the BBM Congress comes to a close, we’re leaving inspired by the wealth of insightful lect…
- [ESSO Oncoplastic Breast Surgery Interactive Workshop and Masterclass 2025 at Dubai](https://advancedbioconcept.com/esso-oncoplastic-and-breast-reconstruction-masterclass/): ABC had the privilege of attending the 2nd ESSO Oncoplastic Breast Surgery Interactive Workshop and Masterclass in the Middle East, organized in collaboratio…
- [Surgery At Sant Pau Hospital in Barcelona by dr. Gemma Pons](https://advancedbioconcept.com/exashape-bioshield-pocket-success-santpau-hospital-pons/): Successful Clinical Application of Bioshield Technology At Sant Pau Hospital in Barcelona, Dr. Gemma Pons, MD, PhD, a skilled plastic surgeon from Dr. Jaume…
- [Surgery At Sant Pau Hospital in Barcelona by dr. Irene Laura Lusetti](https://advancedbioconcept.com/exashape-surgery-success-santpau-hospital-lusetti/): Innovative Techniques with the Exashape Bioshield Pocket Membrane At Sant Pau Hospital in Barcelona, Dr. Irene Laura Lusetti, MD, PhD, a skilled plastic surg…
- [Milestone Breast Reconstruction Surgery in Austria](https://advancedbioconcept.com/milestone-breast-reconstruction-surgery-in-austria/): Advancing Reconstructive Surgery with Exashape At Krems University Hospital in Austria on January 15, 2025, Exashape continues to drive innovation in breast…
- [Breast Reconstruction Insights by Pier Camillo Parodi in Lisbon](https://advancedbioconcept.com/breast-reconstruction-surgery-lisbon/): The Role of Acellular Matrices in Modern Surgery In Lisbon, we had the privilege of hosting another outstanding medical education event in partnership with E…
- [Breast Reconstruction Insights by Giovanni Zoccali in Belfast](https://advancedbioconcept.com/medical-education-event-in-belfast/): we were thrilled to host another inspiring educational event in partnership with Balmain Medical🙌 The evening featured an enlightening session by the excepti…
- [ABC at Swiss Plastic Surgery Congress](https://advancedbioconcept.com/abc-at-swiss-plastic-surgery-congress/): 🌟 Join us at the Swiss Plastic Surgery Congress! 🌟📅 When: October 18-19, 2024📍 Where: Lausanne, Switzerland We are thrilled to announce that our partners DAC…
- [Welcome on board, bondimed®](https://advancedbioconcept.com/welcome-on-board-bondimed/): 📢 Welcome on Board: Bondimed Aesthetics GmbH as our new Exclusive Distributor for Austria🤩 We are thrilled to announce a new strategic partnership with Bondi…
- [Training session in italy](https://advancedbioconcept.com/training-session-in-italy/): 🚀 Another productive training session in Rome 🚀 We just wrapped up a fantastic training session with our partners on 23-24th September!The first day focused…
- [The use of Exashape (TM) Bioshield Pocket in prepectoral breast reconstruction: a preliminary experience](https://advancedbioconcept.com/the-use-of-exashape-tm-bioshield-pocket-in-prepectoral-breast-reconstruction-a-preliminary-experience/): by Marco Mazzocchi, Giorgio Sigorini, Eugenio Cerciello, Francesco Barberini Read full article on PRRS Journal
- [A Pericardium Bovine Matrix Pocket in DTI Prepectoral Breast Reconstruction](https://advancedbioconcept.com/a-pericardium-bovine-matrix-pocket-in-dti-prepectoral-breast-reconstruction/): by Roy De Vita, Maria Lucia Mangialardi, Marcello Pozzi, Veronica Vietti Michelina, Jacopo Nanni, Nicola Zingaretti, Pier Camillo Parod, Giovanni Zoccali Rea…
- [International live surgery training with roy de vita](https://advancedbioconcept.com/international-live-surgery-training/): 📣 Announcement of a New Training Course 🙌 ABC is pleased to announce a new unique Live surgery training course on October 15th and 16th.It will be at the Reg…
- [International Board of Expert – JUNE ’24](https://advancedbioconcept.com/international-board-of-expert-june-24/): 💥 Last week we had an incredibly productive IBEx meeting, marked by interesting, innovative, and thought-provoking discussions. The proactive exchange of ide…
- [Successful REconstruction using Exashape by Jaume Masia](https://advancedbioconcept.com/successful-reconstruction-using-exashape-by-jaume-masia/): 🙌 Few day ago Jaume Masia performed a DTI breast reconstruction at the Hospital de la Santa Creu i Sant Pau in Barcelona using our innovative #Exashape Biosh…
- [Scientific Inside – JUNE ’24](https://advancedbioconcept.com/scientific-inside-june-24/): 🩺 Scientific Insights 🩺 Our recent distributors' meeting on June 7th was enriched with a scientific update that captivated everyone in attendance.Special tha…

## Optional

- [Sitemap](https://advancedbioconcept.com/wp-sitemap.xml): every indexable URL on the site.